PART I Bacterial adhesins and adhesive structures
نویسندگان
چکیده
منابع مشابه
Expression of bacterial adhesins in E.coli: From mapping of adhesive epitopes to structure
Cover figure: A stereo view of the surface of the GafD1-178 showing the bound GlcNAc (courtesy of Michael Merckel) CONTENTS LIST OF ORIGINAL PUBLICATIONS SUMMARY 1. INTRODUCTION 1 1.1. The diversity of bacterial adhesins 1 1.2. Bacterial adhesins mediate attachment to a variety of targets 2
متن کاملThe chaperone-usher pathway of bacterial adhesin biogenesis -- from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design.
The chaperone-usher system determines the biogenesis of surface-exposed adhesive structures responsible for virulence of many Gram-negative bacteria. Investigations of the last 20 years have resolved the mechanism of this pathway on a structural level for different species of pathogenic bacteria. The purpose of this review is to present the molecular mechanisms of the biogenesis of adhesive str...
متن کاملDancing to Another Tune—Adhesive Moonlighting Proteins in Bacteria
Biological moonlighting refers to proteins which express more than one function. Moonlighting proteins occur in pathogenic and commensal as well as in Gram-positive and Gram-negative bacteria. The canonical functions of moonlighting proteins are in essential cellular processes, i.e., glycolysis, protein synthesis, chaperone activity, and nucleic acid stability, and their moonlighting functions ...
متن کاملArchitecture and adhesive activity of the Haemophilus influenzae Hsf adhesin.
Haemophilus influenzae type b is an important cause of meningitis and other serious invasive diseases and initiates infection by colonizing the upper respiratory tract. Among the major adhesins in H. influenzae type b is a nonpilus protein called Hsf, a large protein that forms fiber-like structures on the bacterial surface and shares significant sequence similarity with the nontypeable H. infl...
متن کاملTrimeric autotransporters require trimerization of the passenger domain for stability and adhesive activity.
In recent years, structural studies have identified a number of bacterial, viral, and eukaryotic adhesive proteins that have a trimeric architecture. The prototype examples in bacteria are the Haemophilus influenzae Hia adhesin and the Yersinia enterocolitica YadA adhesin. Both Hia and YadA are members of the trimeric-autotransporter subfamily and are characterized by an internal passenger doma...
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تاریخ انتشار 2004